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Celebrating Black History
Month

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CAC Members at an APOLLO Steering Committee Meeting March 4th, 2020 

APOLLO 

APOL1 Long-term Kidney Transplantation
Outcomes Network 

The purpose of this study is to test kidney donors and kidney transplant recipients for apolipoprotein L1 gene (called APOL1) variants (or forms of the gene) and to see how these may affect them. Genes control the traits that you inherit from your family such as your eye color or blood type. Variation or changes in genes can also put some people at risk for developing certain diseases. Previous research has shown that variation in the APOL1 gene can put people at higher risk for kidney disease. The purpose of this study is to test kidney donors and recipients for APOL1 gene variants to see how this gene may impact people who receive a kidney transplant and those who donated a kidney.

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Sylvia Rosas, an APOLLO Clinical Center PI, has a recently published manuscript entitled "Association of Recipient APOL1 Kidney Risk Alleles With Kidney Transplant Outcomes". This manuscript details the results of the observational trial, The Renal Transplant Outcome Study. The study investigated kidney transplant survival among African American recipients within 3 transplant centers in Philadelphia from 1999–2004. Researchers focused on a specific genetic factor called APOL1 risk alleles, and analyzed the outcomes based on the presence of the alleles.

Click the image to read the full article. 

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