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CAC Members at an APOLLO Steering Committee Meeting March 4th, 2020 

APOL1 Long-term Kidney Transplantation
Outcomes Network 

The purpose of this study is to test kidney donors and kidney transplant recipients for apolipoprotein L1 gene (called APOL1) variants (or forms of the gene) and to see how these may affect them. Genes control the traits that you inherit from your family such as your eye color or blood type. Variation or changes in genes can also put some people at risk for developing certain diseases. Previous research has shown that variation in the APOL1 gene can put people at higher risk for kidney disease. The purpose of this study is to test kidney donors and recipients for APOL1 gene variants to see how this gene may impact people who receive a kidney transplant and those who donated a kidney.


The APOLLO Consortium has recently published a manuscript detailing the creation of the Single IRB for the APOLLO study. 

The IRB or Institutional Review Board is put into place with research studies to ensure that the study is going according to regulations, upholds ethical standards, and protects study participants. After 2018, the Single IRB process was put into place to reduce repetition in multi-site trials. 

Click the button to read the article and learn more. 

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