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Ancillary Studies

An ancillary study is a study based on information from APOLLO participants, which may include hypotheses, specific aims, proposals for external funding to support an investigation or analysis that is relevant to, but not described in, the APOLLO protocol.

Look below to learn more about APOLLO's approved ancillary studies. 


Living Donor Extended Time Outcomes (LETO) Study

This study is conducted by researchers at the University of California, San Francisco (UCSF), Saint Louis University, and Wake Forest University Health Sciences. This study is funded by the National Institute of Diabetes and Digestive and Kidney Diseases at the National Institutes of Health. The goal of our study is to understand and improve outcomes in living kidney donors. We seek to understand differences in kidney function after kidney donation among donors of different races.


Blacks in the United States have a higher incidence of end-stage kidney disease than the general population; much, but not all, of this excess risk is attributed to variants in the ApoL1 gene. Individuals with 2 high risk variants—found almost exclusively in people of West African ancestry—have a 20% chance of developing kidney disease. In this 3-year ancillary project we will explore the factors that influence participants’ views on ApoL1 testing clinical practices and obtain an informed consensus among diverse stakeholder groups on clinical practices. We will also explore participants’ experiences with receiving Apol1 testing results.

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